The Neuroscience Working Table (“Working Table”), which includes organizations and coalitions representing more than 100 million Americans with psychiatric and neurologic diseases, writes to express our support for S. 3427, “the Neuroscience Center of Excellence Act of 2021” introduced on December 16, 2021. We commend your leadership in authoring a bill that would require the establishment of a Neuroscience Center of Excellence (NCOE) at the Food and Drug Administration (FDA). The Working Table supports the creation of a NCOE at FDA with the mission of accelerating development, review, and approval of new medical products and achieving patient-centered regulatory decision-making through collaboration, engagement, and transparency.